encephalopathy or Reye's syndrome.

Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Regardless of the administration route, promethazine hydrochloride injection can cause severe chemical irritation and damage to the tissue. Promethazine hydrochloride (10Each mL contains promethazine hydrochloride 25 mg, edetate disodium 0.1 mg, calcium chloride 0.04 mg, sodium metabisulfite 0.25 mg and phenol 5 mg in Water for Injection. However, elderly patients may be more sensitive to the side effects of this medicine than in younger adults, and are more likely to have age-related heart or blood vessel disease or prostate problems, which may require an adjustment in the dose for patients receiving promethazine injection. Promethazine can cause severe breathing problems or death in a child in very young children. When used for control of postoperative nausea and vomiting, the dosage of analgesics and barbiturates should be reduced accordingly (see

Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, antidepressants, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Promethazine hydrochloride injection was nonmutagenic in the Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg (approximately 2.1 and 4.2 times the maximum recommended human daily dose) of promethazine hydrochloride injection. Due to the risks of IV administration, the preferred route of …

Limited experience with dialysis indicates that it is not helpful.Promethazine hydrochloride injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. SeePromethazine hydrochloride injection should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression.

Promethazine hydrochloride injection can cause severe chemical irritation and damage to tissues regardless of the route of administration. The preferred parenteral route of administration for promethazine hydrochloride (promethazine hydrochloride injection) is by deep intramuscular injection. Promethazine hydrochloride injection may cause marked drowsiness or impair the mental or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. This possibility should be considered with promethazine hydrochloride injection.The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride injection:Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.An increase in blood glucose has been reported in patients receiving promethazine hydrochloride.Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine hydrochloride injection, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.Do not use promethazine hydrochloride injection if solution has developed color or contains precipitate.To avoid the possibility of physical and/or chemical incompatibility, consult specialized literature before diluting with any injectable solution or combining with any other medication. Only in cases of extreme overdosage or individual sensitivity do vital signs, including respiration, pulse, blood pressure, temperature, and EKG, need to be monitored. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS).

Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Excessive amounts of promethazine hydrochloride injection relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.Because of the potential for promethazine hydrochloride to reverse epinephrine’s vasopressor effect, epinephrine should NOT be used to treat hypotension associated with promethazine hydrochloride injection overdose.Concomitant use of other agents with anticholinergic properties should be undertaken with caution.Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAO Inhibitors and phenothiazines are used concomitantly. Promethazine hydrochloride injection should be used with caution in pediatric patients 2 years of age and older (see The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Adverse reactions include burning, pain, thrombophlebitis, tissue necrosis, and gangrene, requiring surgical intervention, skin graft and/or amputation in some cases. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Dosage of concomitant analgesic or hypnotic medication should be reduced accordingly (see

For non-prescription products, read the label or package ingredients carefully. Promethazine hydrochloride injection, USP is a sterile, pyrogen-free solution for deep intramuscular or intravenous administration.
Irritation and damage can result from perivascular extravasation, unintentional intra-arterial injection, and intraneuronal or perineuronal infiltration (see The preferred administrative route is intramuscular, which reduces risk of surrounding muscle and tissue damage.